TY - JOUR
T1 - Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica
AU - Sedrakyan, Anahit M.
AU - Ktsoyan, Zhanna A.
AU - Arakelova, Karine A.
AU - Zakharyan, Magdalina K.
AU - Hovhannisyan, Alvard I.
AU - Gevorgyan, Zaruhi U.
AU - Mnatsakanyan, Armine A.
AU - Kakabadze, Elene G.
AU - Makalatia, Khatuna B.
AU - Chanishvili, Nina A.
AU - Pirnay, Jean Paul
AU - Arakelyan, Arsen A.
AU - Aminov, Rustam I.
N1 - Publisher Copyright:
© Copyright © 2020 Sedrakyan, Ktsoyan, Arakelova, Zakharyan, Hovhannisyan, Gevorgyan, Mnatsakanyan, Kakabadze, Makalatia, Chanishvili, Pirnay, Arakelyan and Aminov.
PY - 2020/12/22
Y1 - 2020/12/22
N2 - A total of 291 non-duplicate isolates of non-typhoidal Salmonella (NTS) were collected from the fecal samples of patients with salmonellosis in Armenia and Georgia during 1996–2016. The isolates were tested for resistance to antimicrobials, including extended-spectrum β-lactamases (ESBL). The high prevalence of multidrug-resistance (MDR) and ESBL-producer phenotypes was detected among Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates collected from patients in Armenia between 1996 and 2016. A total of 36 MDR NTS isolates were subjected to whole genome sequencing (WGS) to determine the genetic background of antimicrobial resistance (AMR) and mobile genetic elements. All ESBL-producing S. Typhimurium isolates belonged to the same sequence type (ST328). The ESBL-producer phenotype was associated with plasmid-encoded CTX-M-5 production. A range of other plasmids was associated with resistance to other antimicrobials, including the MDR phenotype.
AB - A total of 291 non-duplicate isolates of non-typhoidal Salmonella (NTS) were collected from the fecal samples of patients with salmonellosis in Armenia and Georgia during 1996–2016. The isolates were tested for resistance to antimicrobials, including extended-spectrum β-lactamases (ESBL). The high prevalence of multidrug-resistance (MDR) and ESBL-producer phenotypes was detected among Salmonella enterica subsp. enterica serovar Typhimurium (S. Typhimurium) isolates collected from patients in Armenia between 1996 and 2016. A total of 36 MDR NTS isolates were subjected to whole genome sequencing (WGS) to determine the genetic background of antimicrobial resistance (AMR) and mobile genetic elements. All ESBL-producing S. Typhimurium isolates belonged to the same sequence type (ST328). The ESBL-producer phenotype was associated with plasmid-encoded CTX-M-5 production. A range of other plasmids was associated with resistance to other antimicrobials, including the MDR phenotype.
KW - WGS
KW - antimicrobial resistance
KW - antimicrobial resistance genes
KW - extended-spectrum β-lactamases
KW - non-typhoidal Salmonella
UR - http://www.scopus.com/inward/record.url?scp=85098980815&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2020.592223
DO - 10.3389/fmicb.2020.592223
M3 - Article
AN - SCOPUS:85098980815
SN - 1664-302X
VL - 11
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 592223
ER -