TY - JOUR
T1 - Case report
T2 - Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy
AU - Van Nieuwenhuyse, Brieuc
AU - Balcaen, Mathilde
AU - Chatzis, Olga
AU - Haenecour, Astrid
AU - Derycke, Emilien
AU - Detaille, Thierry
AU - Clément de Cléty, Stéphan
AU - Boulanger, Cécile
AU - Belkhir, Leïla
AU - Yombi, Jean Cyr
AU - De Greef, Julien
AU - Cornu, Olivier
AU - Docquier, Pierre Louis
AU - Lentini, Audrey
AU - Menten, Renaud
AU - Rodriguez-Villalobos, Hector
AU - Verroken, Alexia
AU - Djebara, Sarah
AU - Merabishvili, Maya
AU - Griselain, Johann
AU - Pirnay, Jean Paul
AU - Houtekie, Laurent
AU - Van der Linden, Dimitri
N1 - Publisher Copyright:
Copyright © 2024 Van Nieuwenhuyse, Balcaen, Chatzis, Haenecour, Derycke, Detaille, Clément de Cléty, Boulanger, Belkhir, Yombi, De Greef, Cornu, Docquier, Lentini, Menten, Rodriguez-Villalobos, Verroken, Djebara, Merabishvili, Griselain, Pirnay, Houtekie and Van der Linden.
PY - 2024
Y1 - 2024
N2 - Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.
AB - Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.
KW - MRSA
KW - Panton and Valentine leukocidin (PVL)
KW - bacteriophage
KW - necrotizing fasciitis
KW - pediatric intensive care unit
KW - phage therapy
UR - http://www.scopus.com/inward/record.url?scp=85205528770&partnerID=8YFLogxK
U2 - 10.3389/fcimb.2024.1354681
DO - 10.3389/fcimb.2024.1354681
M3 - Article
C2 - 39355265
AN - SCOPUS:85205528770
SN - 2235-2988
VL - 14
JO - Frontiers in Cellular and Infection Microbiology
JF - Frontiers in Cellular and Infection Microbiology
M1 - 1354681
ER -