Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Anaïs Eskenazi; Cédric Lood; Julia Wubbolts; Maya Hites; Nana Balarjishvili; Lika Leshkasheli; Lia Askilashvili; Leila Kvachadze; Vera van Noort; Jeroen Wagemans; Marc Jayankura; Nina Chanishvili; Mark de Boer; Peter Nibbering; Mzia Kutateladze; Rob Lavigne; Maya Merabishvili; Jean Paul Pirnay

doi:10.1038/s41467-021-27656-z

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

Anaïs Eskenazi, Cédric Lood, Julia Wubbolts, Maya Hites, Nana Balarjishvili, Lika Leshkasheli, Lia Askilashvili, Leila Kvachadze, Vera van Noort, Jeroen Wagemans, Marc Jayankura, Nina Chanishvili, Mark de Boer, Peter Nibbering, Mzia Kutateladze, Rob Lavigne, Maya Merabishvili, Jean Paul Pirnay

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Résumé

A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions.

langue originale	Anglais
Numéro d'article	302
journal	Nature Communications
Volume	13
Numéro de publication	1
Les DOIs	https://doi.org/10.1038/s41467-021-27656-z
état	Publié - déc. 2022

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Eskenazi, A., Lood, C., Wubbolts, J., Hites, M., Balarjishvili, N., Leshkasheli, L., Askilashvili, L., Kvachadze, L., van Noort, V., Wagemans, J., Jayankura, M., Chanishvili, N., de Boer, M., Nibbering, P., Kutateladze, M., Lavigne, R., Merabishvili, M., & Pirnay, J. P. (2022). Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae. Nature Communications, 13(1), Article 302. https://doi.org/10.1038/s41467-021-27656-z

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title = "Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae",

abstract = "A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient{\textquoteright}s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient{\textquoteright}s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions.",

author = "Ana{\"i}s Eskenazi and C{\'e}dric Lood and Julia Wubbolts and Maya Hites and Nana Balarjishvili and Lika Leshkasheli and Lia Askilashvili and Leila Kvachadze and {van Noort}, Vera and Jeroen Wagemans and Marc Jayankura and Nina Chanishvili and {de Boer}, Mark and Peter Nibbering and Mzia Kutateladze and Rob Lavigne and Maya Merabishvili and Pirnay, {Jean Paul}",

note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2022",

month = dec,

doi = "10.1038/s41467-021-27656-z",

language = "English",

volume = "13",

journal = "Nature Communications",

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Eskenazi, A, Lood, C, Wubbolts, J, Hites, M, Balarjishvili, N, Leshkasheli, L, Askilashvili, L, Kvachadze, L, van Noort, V, Wagemans, J, Jayankura, M, Chanishvili, N, de Boer, M, Nibbering, P, Kutateladze, M, Lavigne, R, Merabishvili, M & Pirnay, JP 2022, 'Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae', Nature Communications, VOL. 13, Numéro 1, 302. https://doi.org/10.1038/s41467-021-27656-z

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T1 - Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

AU - Eskenazi, Anaïs

AU - Lood, Cédric

AU - Wubbolts, Julia

AU - Hites, Maya

AU - Balarjishvili, Nana

AU - Leshkasheli, Lika

AU - Askilashvili, Lia

AU - Kvachadze, Leila

AU - van Noort, Vera

AU - Wagemans, Jeroen

AU - Jayankura, Marc

AU - Chanishvili, Nina

AU - de Boer, Mark

AU - Nibbering, Peter

AU - Kutateladze, Mzia

AU - Lavigne, Rob

AU - Merabishvili, Maya

AU - Pirnay, Jean Paul

PY - 2022/12

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AB - A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term (>700 days) antibiotic therapy is treated with a pre-adapted bacteriophage along with meropenem and colistin, followed by ceftazidime/avibactam. This salvage therapy results in objective clinical, microbiological and radiological improvement of the patient’s wounds and overall condition. In support, the bacteriophage and antibiotic combination is highly effective against the patient’s K. pneumoniae strain in vitro, in 7-day mature biofilms and in suspensions.

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Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

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