Trait Interindividual Differences in the Effectiveness of Modafinil

Jeroen Van Cutsem; Emilie Dessy; Martine Van Puyvelde; Olivier Mairesse; Xavier Neyt; Nathalie Pattyn

doi:10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil

Jeroen Van Cutsem, Emilie Dessy, Martine Van Puyvelde, Olivier Mairesse, Xavier Neyt, Nathalie Pattyn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

Original language	English
Title of host publication	Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021
Editors	Pedro M. Arezes, Ronald L. Boring
Publisher	Springer Science and Business Media Deutschland GmbH
Pages	12-20
Number of pages	9
ISBN (Print)	9783030802875
DOIs	https://doi.org/10.1007/978-3-030-80288-2_2
Publication status	Published - 2021
Event	AHFE International Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021 - Virtual, Online Duration: 25 Jul 2021 → 29 Jul 2021

Publication series

Name	Lecture Notes in Networks and Systems
Volume	262 LNNS
ISSN (Print)	2367-3370
ISSN (Electronic)	2367-3389

Conference

Conference	AHFE International Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021
City	Virtual, Online
Period	25/07/21 → 29/07/21

Keywords

Human performance
Interindividual differences
Psychostimulant

Access to Document

10.1007/978-3-030-80288-2_2

Cite this

Cutsem, J. V., Dessy, E., Puyvelde, M. V., Mairesse, O., Neyt, X., & Pattyn, N. (2021). Trait Interindividual Differences in the Effectiveness of Modafinil. In P. M. Arezes, & R. L. Boring (Eds.), Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021 (pp. 12-20). (Lecture Notes in Networks and Systems; Vol. 262 LNNS). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/978-3-030-80288-2_2

Cutsem, Jeroen Van ; Dessy, Emilie ; Puyvelde, Martine Van et al. / Trait Interindividual Differences in the Effectiveness of Modafinil. Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021. editor / Pedro M. Arezes ; Ronald L. Boring. Springer Science and Business Media Deutschland GmbH, 2021. pp. 12-20 (Lecture Notes in Networks and Systems).

@inproceedings{a590f73e323e49c3814bfa595c915887,

title = "Trait Interindividual Differences in the Effectiveness of Modafinil",

abstract = "Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.",

keywords = "Human performance, Interindividual differences, Psychostimulant",

author = "Cutsem, {Jeroen Van} and Emilie Dessy and Puyvelde, {Martine Van} and Olivier Mairesse and Xavier Neyt and Nathalie Pattyn",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.; AHFE International Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021 ; Conference date: 25-07-2021 Through 29-07-2021",

year = "2021",

doi = "10.1007/978-3-030-80288-2_2",

language = "English",

isbn = "9783030802875",

series = "Lecture Notes in Networks and Systems",

publisher = "Springer Science and Business Media Deutschland GmbH",

pages = "12--20",

editor = "Arezes, {Pedro M.} and Boring, {Ronald L.}",

booktitle = "Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021",

}

Cutsem, JV, Dessy, E, Puyvelde, MV, Mairesse, O, Neyt, X & Pattyn, N 2021, Trait Interindividual Differences in the Effectiveness of Modafinil. in PM Arezes & RL Boring (eds), Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021. Lecture Notes in Networks and Systems, vol. 262 LNNS, Springer Science and Business Media Deutschland GmbH, pp. 12-20, AHFE International Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021, Virtual, Online, 25/07/21. https://doi.org/10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil. / Cutsem, Jeroen Van; Dessy, Emilie; Puyvelde, Martine Van et al.
Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021. ed. / Pedro M. Arezes; Ronald L. Boring. Springer Science and Business Media Deutschland GmbH, 2021. p. 12-20 (Lecture Notes in Networks and Systems; Vol. 262 LNNS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Trait Interindividual Differences in the Effectiveness of Modafinil

AU - Cutsem, Jeroen Van

AU - Dessy, Emilie

AU - Puyvelde, Martine Van

AU - Mairesse, Olivier

AU - Neyt, Xavier

AU - Pattyn, Nathalie

N1 - Publisher Copyright: © The Author(s), under exclusive license to Springer Nature Switzerland AG 2021.

PY - 2021

Y1 - 2021

N2 - Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

AB - Purpose: To optimize the usage of modafinil as a cognitive enhancer and increase safety and effectiveness, we sought to assess the trait-characteristic of modafinil-sensitivity. Methods: 11 healthy participants (age = 21 ± 2 yr) were tested on 2 separate occasions during which they were sleep deprived for one night. During one trial they received 2 × 200 mg modafinil (i.e. EXP); during the other they received 2 × a placebo-capsule (i.e. CON). Physiological (e.g. heart rate and blood pres-sure), subjective (e.g. sleepiness and mood state) and behavioral (e.g. psychomotor vigilance task) measures of sleep-wake regulation were followed up. Results: Both PVT performance and perceived sleepiness were significantly improved in EXP at 2AM and 4AM during the sleep deprivation-night, compared to in CON. Additionally, an ICC of 0.90 for the delta (CON – EXP) in non-adjusted reaction time was observed. Conclusion: Stable and robust interindividual differences in modafinil-sensitivity are clearly present across day and night.

KW - Human performance

KW - Interindividual differences

KW - Psychostimulant

UR - http://www.scopus.com/inward/record.url?scp=85123825713&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-80288-2_2

DO - 10.1007/978-3-030-80288-2_2

M3 - Conference contribution

AN - SCOPUS:85123825713

SN - 9783030802875

T3 - Lecture Notes in Networks and Systems

SP - 12

EP - 20

BT - Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021

A2 - Arezes, Pedro M.

A2 - Boring, Ronald L.

PB - Springer Science and Business Media Deutschland GmbH

T2 - AHFE International Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021

Y2 - 25 July 2021 through 29 July 2021

ER -

Cutsem JV, Dessy E, Puyvelde MV, Mairesse O, Neyt X , Pattyn N. Trait Interindividual Differences in the Effectiveness of Modafinil. In Arezes PM, Boring RL, editors, Advances in Safety Management and Human Performance - Proceedings of the AHFE 2021 Virtual Conferences on Safety Management and Human Factors, and Human Error, Reliability, Resilience, and Performance, 2021. Springer Science and Business Media Deutschland GmbH. 2021. p. 12-20. (Lecture Notes in Networks and Systems). doi: 10.1007/978-3-030-80288-2_2

Trait Interindividual Differences in the Effectiveness of Modafinil

Abstract

Publication series

Conference

Keywords

Access to Document

Other files and links

Fingerprint

Cite this