TY - JOUR
T1 - Selection and Characterization of a Candidate Therapeutic Bacteriophage That Lyses the Escherichia coli O104:H4 Strain from the 2011 Outbreak in Germany
AU - Merabishvili, Maia
AU - de Vos, Daniel
AU - Verbeken, Gilbert
AU - Kropinski, Andrew M.
AU - Vandenheuvel, Dieter
AU - Lavigne, Rob
AU - Wattiau, Pierre
AU - Mast, Jan
AU - Ragimbeau, Catherine
AU - Mossong, Joel
AU - Scheres, Jacques
AU - Chanishvili, Nina
AU - Vaneechoutte, Mario
AU - Pirnay, Jean Paul
PY - 2012/12/21
Y1 - 2012/12/21
N2 - In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections.
AB - In 2011, a novel strain of O104:H4 Escherichia coli caused a serious outbreak of foodborne hemolytic uremic syndrome and bloody diarrhea in Germany. Antibiotics were of questionable use and 54 deaths occurred. Candidate therapeutic bacteriophages that efficiently lyse the E. coli O104:H4 outbreak strain could be selected rather easily from a phage bank or isolated from the environment. It is argued that phage therapy should be more considered as a potential armament against the growing threat of (resistant) bacterial infections.
UR - http://www.scopus.com/inward/record.url?scp=84871385638&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0052709
DO - 10.1371/journal.pone.0052709
M3 - Article
C2 - 23285164
AN - SCOPUS:84871385638
SN - 1932-6203
VL - 7
JO - PLoS ONE
JF - PLoS ONE
IS - 12
M1 - e52709
ER -