TY - JOUR
T1 - Excitatory versus inhibitory impairments in insomnia patients
T2 - An ERP study
AU - Cortoos, Aisha
AU - De Valck, Elke
AU - Pattyn, Nathalie
AU - Mairesse, Olivier
AU - Cluydts, Raymond
N1 - Funding Information:
This study was supported by the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (Belgium) , research grant FWO G.0067.05. and the Onderzoeksraad (OZR) of the Vrije Universiteit Brussel.
PY - 2014/7
Y1 - 2014/7
N2 - According to the neurocognitive perspective on insomnia, conditioned arousal results in impairment of information processing, as such interfering with normal sleep processes. In the present study, evening event-related potentials N100 and P200 were evaluated to assess hyperarousal in patients with insomnia and controls. 13 patients (mean age. = 40.8) with polysomnographically verified sleep disruptions and 11 good sleepers (mean age. = 45.4) were included. An auditory oddball paradigm was administered the evening of the polysomnography. N100 and P200 mean amplitudes and peak latencies at Fz and Cz were analyzed as a measure of respectively general arousability and inhibition of information processing. Patients experiencing insomnia were characterized by decreased P200 amplitudes compared to good sleepers. No significant differences were found for N100 amplitudes and latencies of both ERP waves.These results suggest that this group of patients with objectified insomnia is characterized by an arousal impairment. However, there was no evidence of hyperarousal, considering the normal N100 amplitudes. On the other hand, the inhibition of information processing was distorted. As such, the impairment of de-arousal or de-activation in insomnia is put forward as an additional factor within the arousal model.
AB - According to the neurocognitive perspective on insomnia, conditioned arousal results in impairment of information processing, as such interfering with normal sleep processes. In the present study, evening event-related potentials N100 and P200 were evaluated to assess hyperarousal in patients with insomnia and controls. 13 patients (mean age. = 40.8) with polysomnographically verified sleep disruptions and 11 good sleepers (mean age. = 45.4) were included. An auditory oddball paradigm was administered the evening of the polysomnography. N100 and P200 mean amplitudes and peak latencies at Fz and Cz were analyzed as a measure of respectively general arousability and inhibition of information processing. Patients experiencing insomnia were characterized by decreased P200 amplitudes compared to good sleepers. No significant differences were found for N100 amplitudes and latencies of both ERP waves.These results suggest that this group of patients with objectified insomnia is characterized by an arousal impairment. However, there was no evidence of hyperarousal, considering the normal N100 amplitudes. On the other hand, the inhibition of information processing was distorted. As such, the impairment of de-arousal or de-activation in insomnia is put forward as an additional factor within the arousal model.
KW - Arousal
KW - Event-related potentials
KW - Inhibition
KW - Insomnia
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=84904762517&partnerID=8YFLogxK
U2 - 10.1016/j.ijpsycho.2013.03.004
DO - 10.1016/j.ijpsycho.2013.03.004
M3 - Article
C2 - 23541997
AN - SCOPUS:84904762517
SN - 0167-8760
VL - 93
SP - 62
EP - 69
JO - International Journal of Psychophysiology
JF - International Journal of Psychophysiology
IS - 1
ER -