Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis

Saartje Uyttebroek; Lieven Dupont; Jeroen Wagemans; Rob Lavigne; Maya Merabishvili; Tom Coenye; Laura Van Gerven

doi:10.1002/alr.23441

Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis

Saartje Uyttebroek, Lieven Dupont, Jeroen Wagemans, Rob Lavigne, Maya Merabishvili, Tom Coenye, Laura Van Gerven

Laboratory for Molecular and Cellular Technology

Research output: Contribution to journal › Article › peer-review

Abstract

Key points: Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms. NaHCO₃ salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.

Original language	English
Pages (from-to)	73-76
Number of pages	4
Journal	International Forum of Allergy and Rhinology
Volume	15
Issue number	1
DOIs	https://doi.org/10.1002/alr.23441
Publication status	Published - Jan 2025

Keywords

CRS
bacteriophages
biofilm
chronic rhinosinusitis
phage
treatment

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10.1002/alr.23441

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title = "Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis",

abstract = "Key points: Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms. NaHCO3 salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.",

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AU - Wagemans, Jeroen

AU - Lavigne, Rob

AU - Merabishvili, Maya

AU - Coenye, Tom

AU - Van Gerven, Laura

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N2 - Key points: Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms. NaHCO3 salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.

AB - Key points: Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms. NaHCO3 salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not. Phage effectivity varies and depends on the phage and the combination with antibiotics.

KW - CRS

KW - bacteriophages

KW - biofilm

KW - chronic rhinosinusitis

KW - phage

KW - treatment

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Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis

Abstract

Keywords

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