Determinants of water proton T1 in blood serum

H. H. Raeymaekers; Dirk Borghys; H. Eisendrath

doi:10.1002/mrm.1910060209

Determinants of water proton T₁ in blood serum

H. H. Raeymaekers, Dirk Borghys, H. Eisendrath

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Vrije Universiteit Brussel

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Abstract

Water proton T₁ (10.7 MHz; 7°C) and albumin and globulin contents were measured in the blood serum of 30 normal volunteers. The T₁ relaxivity of serum albumin and globulin (i.e., the change of water relaxation rate l/T₁ per concentration unit) was determined in pure albumin and globulin solutions. It is shown that more than 90% of the serum relaxation rate 1/T_l is due to the proteins, making T₁ a nonspecific blood parameter. In addition five pathological serum samples were examined, explaining clearly why serum T₁is not a clinically useful measurement. © 1988 Academic Press, Inc.

Original language	English
Pages (from-to)	212-216
Number of pages	5
Journal	Magnetic Resonance in Medicine
Volume	6
Issue number	2
DOIs	https://doi.org/10.1002/mrm.1910060209
Publication status	Published - Feb 1988

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abstract = "Water proton T1 (10.7 MHz; 7°C) and albumin and globulin contents were measured in the blood serum of 30 normal volunteers. The T1 relaxivity of serum albumin and globulin (i.e., the change of water relaxation rate l/T1 per concentration unit) was determined in pure albumin and globulin solutions. It is shown that more than 90% of the serum relaxation rate 1/Tl is due to the proteins, making T1 a nonspecific blood parameter. In addition five pathological serum samples were examined, explaining clearly why serum T1is not a clinically useful measurement. {\textcopyright} 1988 Academic Press, Inc.",

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AU - Borghys, Dirk

AU - Eisendrath, H.

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N2 - Water proton T1 (10.7 MHz; 7°C) and albumin and globulin contents were measured in the blood serum of 30 normal volunteers. The T1 relaxivity of serum albumin and globulin (i.e., the change of water relaxation rate l/T1 per concentration unit) was determined in pure albumin and globulin solutions. It is shown that more than 90% of the serum relaxation rate 1/Tl is due to the proteins, making T1 a nonspecific blood parameter. In addition five pathological serum samples were examined, explaining clearly why serum T1is not a clinically useful measurement. © 1988 Academic Press, Inc.

AB - Water proton T1 (10.7 MHz; 7°C) and albumin and globulin contents were measured in the blood serum of 30 normal volunteers. The T1 relaxivity of serum albumin and globulin (i.e., the change of water relaxation rate l/T1 per concentration unit) was determined in pure albumin and globulin solutions. It is shown that more than 90% of the serum relaxation rate 1/Tl is due to the proteins, making T1 a nonspecific blood parameter. In addition five pathological serum samples were examined, explaining clearly why serum T1is not a clinically useful measurement. © 1988 Academic Press, Inc.

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DO - 10.1002/mrm.1910060209

M3 - Comment/debate

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VL - 6

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JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -

Determinants of water proton T₁ in blood serum

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