TY - JOUR
T1 - BDNF, IGF-I, Glucose and Insulin during Continuous and Interval Exercise in Type 1 Diabetes
AU - Tonoli, C.
AU - Heyman, E.
AU - Roelands, B.
AU - Buyse, L.
AU - Piacentini, F.
AU - Berthoin, S.
AU - Bailey, S.
AU - Pattyn, N.
AU - Meeusen, R.
N1 - Publisher Copyright:
© Georg Thieme Verlag KG Stuttgart, New York.
PY - 2015/3/6
Y1 - 2015/3/6
N2 - Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO2 max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health in T1D, but both types of exercise can be implemented.
AB - Type 1 diabetes (T1D) can have a significant impact on brain function, mostly ascribed to episodes of hypoglycemia and chronic hyperglycemia. Exercise has positive effects on acute and chronic glycemic control in T1D, and has beneficial effects on cognitive function by increasing neurotrophins such as BDNF and IGF-I in non-diabetic humans. The present study examines the effects of different types of exercise intensities on neurotrophins in T1D. 10 participants with type 1 diabetes were evaluated in 3 sessions: high-intensity exercise (10×[60 s 90%Wmax, 60 s 50 W]), continuous exercise (22 min, 70% VO2 max) and a control session. Blood glucose, serum free insulin, serum BDNF and IGF-I were assessed pre/post all the trials and after recovery. Blood glucose significantly decreased after both exercise intensities and BDNF levels increased, with a dose-response effect for exercise intensity on BDNF. IGF-I changed over time, but without a difference between the different exercise protocols. Both exercise intensities change neurotrophins in T1D, but also exhibit a dose response effect for BDNF. The intensity-dependent findings may aid in designing exercise prescriptions for maintaining or improving neurological health in T1D, but both types of exercise can be implemented.
KW - cognition
KW - cognitive function
KW - diabetes
KW - neurotrophins
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=84945437884&partnerID=8YFLogxK
U2 - 10.1055/s-0035-1548886
DO - 10.1055/s-0035-1548886
M3 - Article
C2 - 26212245
AN - SCOPUS:84945437884
SN - 0172-4622
VL - 36
SP - 955
EP - 959
JO - International Journal of Sports Medicine
JF - International Journal of Sports Medicine
IS - 12
ER -