Projects per year
Personal profile
Biography
I graduated from Javakhishvili Tbilisi State University, Georgia, faculty of Biology with MSc degree of honor, specialization in Genetics in 1995. MSc thesis study I have done in collaboration with the Eliava Institute of Bacteriophage, Microbiology and Virology (Eliava IBMV). Title of M.Sc. thesis was: "Phage mediated transduction occurring among S. aureus strains".
Further I continued my professional career as a researcher in the Eliava IBMV. The Eliava Institute represents the world-known research center for bacteriophage therapy with 100 years of history. The Institute owns the world’s largest collection of therapeutic phages. In 2002 I obtained PhD in Biology at the Eliava IBMV in collaboration with the Javakhishvili Tbilisi State University and the University of Oulu (Oulu, Finland). Title of Ph.D. thesis was: "Study of bacterial composition of Matsoni starters collected in the different regions of Georgia". During my PhD studies I twice gained George Soros ISSEP Ph.D. Student Award fellowship.
I did my postdoctoral studies at the University of Milan (UNIMI) (Milan, Italy) and the University of Ghent (UGent) (Ghent, Belgium) during 2002-2006 years.
During the period of 1995-2009 while working at the Eliava Institute I participated in up to 15 projects funded by different international funding sources.
Since 2009, I have been working as a senior scientist in the Laboratory for Molecular and Cellular Technology (LabMCT) of the Queen Astrid Military Hospital (QAMH) in Brussels and have been involved in several research projects associated with bacteriophage and bacteriophage therapy research. The projects have been funded by Royal Military Academy (Belgian defense).
Research interests
Bacteriophages and phage therapy present main interests in my research. Starting from
Master thesis in the Eliava Institute till present I had chance to work and I gained large knowledge and experience in isolation and characterization of bacteriophages active against wide variety of clinical pathogens, selection of potential therapeutic bacteriophages based on essential requirements, genetic characterization of bacteriophages, different production methods of bacteriophage therapeutics on small and large scales.
During my PhD study I worked on molecular characterization of probiotic strains isolated from Georgian traditional dairy products. Research topics of my postdoc studies in Milan University included development of molecular biology strategies for identification of Bacillus spp; molecular characterization and typing of Bacillus anthracis strains isolated in anthrax endemic regions of Georgia. The second postdoctoral studies performed with collaboration Ghent University included development of fRFLP as rapid identification and typing method of dsDNA bacteriophages.
Since the start of my career in 2009 at LabMCT, Queen Astrid Military Hospital, together with Dr Pirnay and his team we were able to establish phage therapy research group and center. In 2018 our team was the initiator to introduce “magistral phage” framework in Belgium. This framework allowed us to treat about 190 patients until now, with 48 different phages, targeting 14 bacterial species (including all ESKAPE pathogens). Due to these efforts and results nowadays Belgium is considered as a pioneer country to re-introduce Bacteriophage Therapy into the modern medicine.
Education/Academic qualification
Other, PhD, Study of bacterial composition of Matsoni starters collected in the different regions of Georgia, George Eliava Institute of Bacteriophage, Microbiology and Virology
1 Mar 1996 → 4 Feb 2002
Award Date: 4 Feb 2002
Other, Master, Phage mediated transduction occurring among S. aureus strains, Ivane Javakhishvili Tbilisi State University
1 Sept 1990 → 1 Jun 1995
Award Date: 1 Jun 1995
External positions
Leading researcher, George Eliava Institute of Bacteriophage, Microbiology and Virology
2002 → Sept 2009
Junior researcher, George Eliava Institute of Bacteriophage, Microbiology and Virology
1995 → 2002
Keywords
- QR355 Virology
- Bacteriophage
- Phage therapy
- Microbiology
- Molecular biology
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Collaborations and top research areas from the last five years
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Research in support of personalized bacteriophage therapy of difficult-to-treat infections
Merabishvili, M. (Researcher), Pirnay, J.-P. (Researcher), Steurs, G. (Researcher) & Cochez, C. (Researcher)
1/01/24 → 31/12/27
Project: Research
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HFM/19-12: Monitoring of bacteria-phage co-evolution during phage therapy of Pseudomonas aeruginosa infected burn wounds
Pirnay, J.-P. (Promotor), Merabishvili, M. (Researcher) & Steurs, G. (Researcher)
1/01/19 → 31/12/23
Project: Research
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HFM/15-5: Mycobacteriophage therapy
Pirnay, J.-P. (Promotor) & Merabishvili, M. (Researcher)
1/01/15 → 31/12/19
Project: Research
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Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis
Uyttebroek, S., Dupont, L., Wagemans, J., Lavigne, R., Merabishvili, M., Coenye, T. & Van Gerven, L., Jan 2025, In: International Forum of Allergy and Rhinology. 15, 1, p. 73-76 4 p.Research output: Contribution to journal › Article › peer-review
Open Access -
How to: assess patient suitability for unlicensed phage therapy in the United Kingdom
Jones, J. D., Stacey, H. J., Kennedy, J. W., Merabishvilli, M., Haines, M. E. K., Blocker, O., Dharmasena, K., Gordon, A., Hamilton, S. A., Aggarwal, I., Nagy, J., Urquhart, D. S., Hall, L. M. L., Young, M. J., MacGregor, G., Langley, R. J., Peters, C. & Munteanu, D. I., Jan 2025, In: Clinical Microbiology and Infection. 31, 1, p. 57-61 5 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle
Verheul, M., Mulder, A. A., van Dun, S. C. J., Merabishvili, M., Nelissen, R. G. H. H., de Boer, M. G. J., Pijls, B. G. & Nibbering, P. H., Dec 2024, In: Springer Scientific Reports. 14, 1, 14374.Research output: Contribution to journal › Article › peer-review
Open Access -
Bacteriophage Production in Compliance with Regulatory Requirements
Pirnay, J. P., Merabishvili, M., De Vos, D. & Verbeken, G., 2024, Methods in Molecular Biology. Humana Press Inc., p. 89-115 27 p. (Methods in Molecular Biology; vol. 2734).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Bacteriophages as potential antibiotic potentiators in cystic fibrosis: A new model to study the combination of antibiotics with a bacteriophage cocktail targeting dual species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa
Wang, Z., De Soir, S., Glorieux, A., Merabishvili, M., Knoop, C., De Vos, D., Pirnay, J. P. & Van Bambeke, F., Sept 2024, In: International Journal of Antimicrobial Agents. 64, 3, 107276.Research output: Contribution to journal › Article › peer-review
Activities
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1st workshop BSVoM: PERSONALISED PHAGE THERAPY: FROM THE LAB TO THE PATIENT
Merabishvili, M. (Organiser)
8 Dec 2022 → 9 Dec 2022Activity: Participating in or organising an event (conference, measurement campaign, ...) › Organising a conference, workshop, ... (outside RMA)
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2nd BSVoM workshop: Personalized phage therapy: from lab to the patient
Merabishvili, M. (Organiser)
28 Nov 2024 → 29 Nov 2024Activity: Participating in or organising an event (conference, measurement campaign, ...) › Organising a conference, workshop, ... (outside RMA)
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NATO STO RTG HFM-313: Re-introduction of phage therapy in military medicine
Merabishvili, M. (Member)
2019 → 2024Activity: Other › Participation to a NATO STO RTG/ET
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Phage therapy for the treatment of MDR pathogens
Merabishvili, M. (Keynote speaker)
15 Oct 2023Activity: Talk or presentation › Scientific talk (Invited speaker)
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Riley Alvarez
Merabishvili, M. (Host)
1 Jul 2024 → 2 Jul 2024Activity: Hosting a visitor › Hosting of a foreign student
Prizes
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Martin Ramelot research prize
Pirnay, J.-P. (Recipient) & Merabishvili, M. (Recipient), 11 Oct 2009
Prize